Comprehensive Nonclinical Safety Assessment of Nirmatrelvir Supporting Timely Development of the SARS-COV-2 Antiviral Therapeutic, Paxlovid™SARS-COV-2 항바이러스 치료제 Paxlovid™의 적시 개발을 지원하는 Nirmatrelvir의 포괄적인 비임상 안전성 평가Article Published on 2022-08-012022-09-11 Journal: International journal of toxicology [Category] 치료제, [키워드] 3CL administration Antiviral Arrhythmias assessment blood pressure cardiovascular caused clinical development Clinical pathology coagulation time Comprehensive conducted COVID-19 COVID-19 patient COVID-19 patients death decrease decreases development dose Drug safety Effect Efficacy Endpoint enhancer enzyme functional heart rate high risk highest dose Hospitalization Increases increases in induce Infection locomotor male MPro nervous system Nirmatrelvir not affect pathology Paxlovid pharmacokinetic Potential produced profile protease RATs Replication respiratory rate Ritonavir Safety safety pharmacology SARS-CoV-2 SARS-CoV-2 virus Support Supporting target tested the SARS-CoV-2 virus toxicities Toxicity toxicology toxicology. transaminase transaminases Treatment treatment of COVID-19 were assessed [DOI] 10.1177/10915818221095489 PMC 바로가기 [Article Type] Article
Vaccination and variants: Retrospective model for the evolution of Covid-19 in Italy예방 접종 및 변종: 이탈리아의 Covid-19 진화에 대한 회고 모델Article Published on 2022-07-082022-09-11 Journal: PLoS ONE [Category] COVID19(2023년), SARS, 변종, [키워드] absence appearance changes characterized combined effect compartmental model contagious COVID-19 pandemic deaths decreases delta variant develop dominant effective Effects epidemiological Evolution followed by individual induce Infection Italy measure mechanism mechanisms normality omicron Omicron variant pandemic Particular predict Retrospective analysis seasonal variation stability vaccination Vaccine Variability variant Variation virus virus infectivity waning immunity [DOI] 10.1371/journal.pone.0265159 PMC 바로가기 [Article Type] Article
The impact of the resumption of in-person school attendance on COVID-affected child abuse and neglect trends in Florida대면 학교 출석 재개가 플로리다의 COVID-영향을 받은 아동 학대 및 방치 추세에 미치는 영향Article Published on 2022-07-012022-09-11 Journal: Child abuse & neglect [Category] COVID19(2023년), SARS, 변종, [키워드] analysis calculated Care Child abuse Child abuse and neglect. Child welfare children concert COVID-19 COVID-19 pandemic cumulative decrease decreases determine executive foster foster care information neglect omicron organization pandemic Predictive Predictive analytics regression equation School Schools secondary significant increase statistically significant variant were used [DOI] 10.1016/j.chiabu.2022.105658 PMC 바로가기 [Article Type] Article
Coagulopathy and Fibrinolytic Pathophysiology in COVID-19 and SARS-CoV-2 VaccinationCOVID-19 및 SARS-CoV-2 백신 접종에서의 응고증 및 섬유소 용해성 병태생리학Review Published on 2022-03-192022-09-11 Journal: International Journal of Molecular Sciences [Category] SARS, 바이오마커, 치료기술, [키워드] Activation acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 antibody argatroban bleeding caused cerebral venous sinuse cerebral venous sinuses characterized Coagulation Coagulopathy coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 D-dimer decrease decreases Disseminated intravascular coagulation enhanced-fibrinolytic-type DIC enzyme enzyme-linked immunosorbent enzyme-linked immunosorbent assay fibrinogen fibrinolysis fibrinolytic fondaparinux high risk High-dose immune Immunoglobulin IMPROVE in some increases in intravascular coagulation nafamostat nafamostat. occur outcomes Platelet Platelets respiratory resulting SARS-CoV-2 SARS-CoV-2 vaccine SARS-CoV-2 vaccines severe acute respiratory syndrome Coronavirus severe COVID-19 thrombosis thrombotic Thrombotic thrombocytopenia Treatment vaccination visceral [DOI] 10.3390/ijms23063338 PMC 바로가기 [Article Type] Review
Biomarker identification using dynamic time warping analysis: a longitudinal cohort study of patients with COVID-19 in a UK tertiary hospital동적 시간 왜곡 분석을 사용한 바이오마커 식별: 영국 3차 병원의 COVID-19 환자에 대한 종단 코호트 연구Article Published on 2022-02-152022-09-11 Journal: BMJ Open [Category] COVID19(2023년), MERS, SARS, 바이오마커, [키워드] Admission Analysis association biochemical biochemical parameter blood tests board C reactive protein change clinical benefit clinical feature clinical response clinical utility COVID-19 CRP D-dimer decrease decreases described determined by discharge discharged disease Disease progression East England Ethical approval ferritin healthcare heterogeneous high mortality highest hospital hospitalised patient Hospitalised patients HRA increase Increases information Informed consent Laboratory Lactate lactate dehydrogenase limit longitudinal change longitudinal changes longitudinal cohort study lowest lymphocyte Lymphocyte count majority Mortality Most patients neutrophil neutrophil counts outcome pandemic Patient patients patients treated patients with COVID-19 Platelet platelet counts prognostic prognostic variable REC respiratory respiratory infections respiratory medicine (see thoracic medicine). retrospective review risk routine blood test routine blood tests SARS-CoV-2 South Specific symptom onset Thoracic Treatment response urea Variation variations waiver was obtained white cell with COVID-19 [DOI] 10.1136/bmjopen-2021-050331 PMC 바로가기 [Article Type] Article
Emergency Department Visits for Nonfatal Opioid Overdose During the COVID-19 Pandemic Across Six US Health Care Systems6개의 미국 의료 시스템에서 COVID-19 전염병 동안 비치명적인 아편유사제 과다 복용으로 인한 응급실 방문Multicenter Study Published on 2022-02-012022-09-11 Journal: Annals of emergency medicine [Category] COVID19(2023년), SARS, 치료기술, [키워드] 95% CI 95% confidence interval Algorithm Analysis chance changes in Community Complication Connecticut Control COVID-19 COVID-19 pandemic cumulative decrease decreases Department disorder Emergency emergency department expected Health care Health care system Healthcare system increase in Intervention Massachusetts North opioid outbreak overdose predicted Rhode Island Social support Support sustained System The United States Treatment United States widespread [DOI] 10.1016/j.annemergmed.2021.03.013 PMC 바로가기 [Article Type] Multicenter Study
Decision support system to evaluate ventilation in the acute respiratory distress syndrome (DeVENT study)—trial protocol급성 호흡 곤란 증후군에서 환기를 평가하기 위한 의사 결정 지원 시스템(DeVENT 연구) - 시험 프로토콜Study Protocol Published on 2022-01-172022-09-10 Journal: Trials [Category] SARS, 임상, [키워드] acute respiratory distress acute respiratory distress syndrome allocation approach ARDS ARDS patient ARDS patients clinical decision clinical trial complex concealed contribute Course COVID-19 COVID-19 pandemic Critical care Decision support decision support system decision support systems decrease decreases determine determined by driving End-Expiratory Pressure evaluate facilitate help IMPROVE improvement International Local lung Lung injury management mathematical Mathematical models mechanical ventilation Mechanical ventilation; Acute respiratory distress syndrome mechanically ventilated mechanically ventilated patient mechanically ventilated patients Mitigation morbidity morbidity and mortality Mortality occur open outcome pandemic Pandemics Patient patients PEEP personalised physiological state point-of-care Positive end-expiratory pressure Pragmatic pressure protective effect Protective effects protocol randomised reduction in respiratory distress Respiratory distress syndrome routine care severity supplementary material Support Support System syndrome variety ventilated patient ventilated patients Ventilation ventilator Ventilator-induced lung injury ventilatory strategy [DOI] 10.1186/s13063-021-05967-2 PMC 바로가기 [Article Type] Study Protocol
Neutralising antibody titres as predictors of protection against SARS-CoV-2 variants and the impact of boosting: a meta-analysisSARS-CoV-2 변이체에 대한 보호 예측 인자로서의 중화 항체 역가 및 부스팅의 영향: 메타 분석Meta-Analysis Published on 2022-01-012022-09-11 Journal: The Lancet. Microbe [Category] MERS, SARS, 변종, 진단, [키워드] Alpha analysed Analysis Antibody titre Beta booster vaccination correlated decrease decreases Effect Efficacy elicited Future In-vitro infected individual Infection infection with SARS-CoV-2 Medical Research Council medium Meta-analysis neutralisation neutralisation titre Neutralising activity not significantly different outcome predict predicted Predictive predictor reduced remained robust SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants serum Severe infection shown statistical model suggested symptomatic infection titre vaccination vaccination schedule Vaccine vaccine efficacy vaccine response vaccine responses Vaccines variant variants variants of concern virus virus infection waning immunity [DOI] 10.1016/S2666-5247(21)00267-6 PMC 바로가기 [Article Type] Meta-Analysis
Reduced neutralisation of the Delta (B.1.617.2) SARS-CoV-2 variant of concern following vaccination델타의 중화 감소 (B.1.617.2) 예방 접종 후 SARS-COV-2 우려 변형Research Article Published on 2021-12-022022-08-13 Journal: PLoS Pathogens [Category] Biochemistry, SARS, 변종, 진단, [키워드] (Beta accumulation African antibody Antibody titre antigenic antigenic drift antigenic profiles assessment Astra Zeneca Author B.1.351 B.1.617.1 B.1.617.2 bat bats Beta BNT162b2 BNT162b2 vaccines Booster vaccine booster vaccines ChAdOx1 changes in collected COVID-19 COVID19 death decrease decreases Delta delta variant dose effective Effectiveness Efficacy elicited evade expressed facilitate fold Fold changes glycoprotein groups hospitalisation Human human cell human cells humans Immunity India indicated individual Infection Lineage magnitude Mutation neutralisation neutralise Neutralising Antibodies neutralising antibody titres of BNT162b2 Pfizer Pfizer/BioNTech Prevent profile protective immune response pseudoviruses recipient recipients reduced reduction reduction in reductions reductions in required risk SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variant SARS-CoV-2 variants SARS-CoV-2 virus sensitivity sera Severe infection shape significantly higher South South Africa spike glycoprotein spike glycoproteins Spike protein subsequent the spike protein titre vaccinated individuals vaccination Vaccine vaccine efficacy Vaccines variant variant B.1.617.2 variants variants of concern Viral viral variant Viral variants virus Virus spike VOCs while with infection with infections Wuhan Wuhan, China [DOI] 10.1371/journal.ppat.1010022 PMC 바로가기 [Article Type] Research Article
Impact of the COVID-19 Pandemic on Objectively Measured Physical Activity and Sedentary Behavior Among Overweight Young Adults: Yearlong Longitudinal Analysis과체중 젊은 성인의 객관적으로 측정된 신체 활동 및 좌식 행동에 대한 COVID-19 팬데믹의 영향: 연간 종단 분석Original Paper Published on 2021-11-242022-09-10 Journal: JMIR Public Health and Surveillance [Category] MERS, SARS, 치료기술, [키워드] 95% CI activity activity monitor activity monitors Adults Algorithm analysis analyzed Bayesian information criterion Behavior breakpoint change changes changes in charge CIs collected conducted COVID-19 COVID-19 mitigation COVID-19 pandemic daily living dating Decline decrease decreases demographic characteristics detect Diego Effect expected Fitbit greater Health health condition Impact impacted implementation lifestyle linear Linear regression model linear regression models LLC longitudinal longitudinal change longitudinal changes lowest minutes not differ obese objective outcome overweight pandemic participant per day physical activity public health Regression model regression models Research Result returned sedentary Sedentary behavior sedentary lifestyle significant decrease significant increases in Trial wearable weight loss were excluded wrist worn young adults [DOI] 10.2196/28317 PMC 바로가기 [Article Type] Original Paper